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The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss. Further, when the gene needed to produce the protein tristetraprolin (TTP) was removed from healthy mice, the animals developed the bones of much older rodents. Within nine months, mice without the gene experienced a nearly 20% loss in oral bone. The results also revealed that over-expressing TTP in the animals led to 13% reduction in bone turnover compared to unaffected mice. Published in the Journal of Dental Research, the study is reportedly the first to test TTP’s influence on bone loss in an animal model. Inflammation is a necessary reaction by the immune system to protect the body from injury or infection, but if not controlled, it can lead to the destruction of bone and the prevention of bone formation.

Source: Protein absence kills bone growth – The Hindu

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