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Patients with type 2 diabetes should be put on diets rich in either animal or plant protein to reduce not only liver fat, but insulin resistance and hepatic necroinflammation markers as well, according to a published study.

“High-protein diets have shown variable and sometimes even favorable effects on glucose metabolism and insulin sensitivity in people with type 2 diabetes and it is unclear which metabolic pathways are involved,” by the German Institute of Human Nutrition Postdam-Rehbrucke in Nuthetal, Germany.

Obesity and insulin resistance have long been linked to liver fat, with excessive amounts of the latter causing nonalcoholic fatty liver disease (NAFLD), with a significant risk of nonalcoholic steatohepatitis, (NASH) developing as well. Compounding this issue, at least in the United States, are widespread dietary and nutritional habits that promote consumption of animal protein, carbohydrates and saturate CDI fats. This “hyper caloric Western style diet,” as the authors call it, exacerbates the accumulation of fat deposits in the liver and complicates health of patients across the country, regardless of the weight.

 

Patients in both cohorts saw significant decreases in intrahepatic fat content by the end of the trial period. Those in the AP cohort saw decreases of 48.0 percent, while those in the PP cohort saw a decrease of 35.7 percent. Perhaps most importantly, the reductions in both cohorts were not correlated to body weight. In addition, levels of fibroblast growth factor 21 (FGF21), which has been shown to be predictive marker of NAFLD, decreased by nearly 50 percent for both AP and PP cohorts.

“Despite the elevated intake and postprandial uptake of methionine and BCAA in the AP group, there was no indication of negative effects of these components,” the authors stated in the study. “The origin of protein – animal or plant – did not play a major role. Both high-protein diets unexpectedly associated with metabolic improvements and the decrease of [intrahepatic lipids].”

Source: Protein-rich diet can help manage type 2 diabetes, NAFLD | Opinion, News, The Philippine Star | philstar.com

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